Nucleotide Powder in Poultry Feed: Everything You Need to Know

What is Nucleotide Powder?

Nucleotide powder is a specialized feed additive that provides poultry with concentrated doses of nucleotides—the essential building blocks of DNA and RNA. These molecules are vital for rapid cell division, tissue repair, and immune system function.

Although birds can synthesize nucleotides naturally, certain situations—such as early growth, disease challenges, or environmental stress—create a demand that exceeds their natural production. Supplementing with dietary nucleotides helps maintain optimal health and performance.

Nucleotide Powder in Poultry Feed

Most Common Sources of Nucleotide Powder

In poultry feed, nucleotide powder typically comes from:

• Yeast extract (Saccharomyces cerevisiae) – the most consistent and widely used source.

• Fish soluble extracts or organ tissue hydrolysates – less common, mostly used in aquaculture and specialty feeds.

• Purified fermentation by-products – derived from biotech processes.

How Nucleotide Powder is Made (Brief Overview)

The most common method uses yeast extract:

1. Cultivate high-RNA yeast under controlled fermentation.

2. Break open yeast cells (autolysis or mechanical disruption) to release nucleic acids.

3. Use enzymatic hydrolysis to break RNA into free nucleotides (AMP, GMP, CMP, UMP).

4. Purify and spray-dry the solution into a fine, stable powder.

Typical Composition of Nucleotide Powder

A high-quality nucleotide powder contains:

• AMP (Adenosine monophosphate) – supports energy metabolism.

• GMP (Guanosine monophosphate) – essential for protein synthesis.

• CMP (Cytidine monophosphate) – important for cell membrane synthesis.

• UMP (Uridine monophosphate) – aids glycogen storage and RNA production.

• IMP (Inosine monophosphate) – precursor to AMP and GMP.

High-quality products usually contain 40–70% total free nucleotides, with the remainder being peptides, amino acids, and beneficial yeast cell wall components like β-glucans.

Benefits of Nucleotide Powder Supplementation in Poultry

1. Growth Performance

• Improves early body weight and daily gain.

• Enhances feed conversion ratio (FCR).

• Supports recovery during stress or disease challenges.

2. Gut Health & Nutrient Absorption

• Increases intestinal villus height, improving nutrient absorption.

• Strengthens the intestinal lining for faster recovery.

3. Immune Support

• Boosts systemic immunity (↑ serum IgG).

• Improves local gut immunity (↑ mucosal IgA).

• Enhances vaccine response (e.g., Newcastle disease).

4. Meat Quality

• Improves meat color, tenderness, and nutrient profile.

5. Stress Resilience

• Reduces losses during heat stress.

• Accelerates recovery from environmental or nutritional stress.

6. Natural Alternative to Antibiotic Growth Promoters (AGPs)

• Maintains gut health and growth naturally, reducing antibiotic use.

What to Look for in a Nucleotide Powder Supplier

When evaluating suppliers, check for:

✅ Source Transparency – high-quality, food-grade yeast origin.

✅ Purity & Concentration – balanced levels of AMP, GMP, CMP, UMP.

✅ Processing Method – enzymatic hydrolysis for maximum bioavailability.

✅ Quality Assurance – strong QC systems and consistency.

✅ Research Support – backed by independent trial data.

✅ Technical Guidance – supplier offers dosage/application advice.

Kshamatva Bioservices – Your Trusted Source

At Kshamatva Bioservices LLP, we provide high-quality yeast-derived nucleotide powder formulated for poultry excellence.

✔ Enzymatically processed for maximum bioavailability✔ Rich in all key nucleotides (AMP, GMP, CMP, UMP, IMP)✔ Consistent, traceable, and rigorously quality-checked✔ Supported by scientific research and technical expertise

Whether your goal is to boost chick start-up performance, strengthen flock immunity, or reduce reliance on AGPs, Kshamatva’s nucleotide powder is a proven solution for modern poultry farming.

📩 Contact us today to learn how our nucleotide solutions can benefit your flock.

References

1. Carver, J. D. (1999). Dietary nucleotides: Cellular immune, intestinal and hepatic system effects. Journal of Nutrition, 129(12 Suppl), 1452S–1456S.

2. Carver, J. D., & Walker, W. A. (1995). The role of nucleotides in human nutrition. Journal of Nutritional Biochemistry, 6(2), 58–72.

3. Cheng, C. H., Wu, P. S., Chen, J. J., & Yu, Y. H. (2017). Effects of dietary nucleotides on growth performance, immune responses and intestinal morphology in broiler chickens. Asian-Australasian Journal of Animal Sciences, 30(1), 64–71.

4. Cosgrove, M. (1998). Nucleotides. Nutrition, 14(9), 748–751.

5. Grimble, G. K., & Westwood, O. M. R. (2001). Nucleotides as immunomodulators in clinical nutrition. Current Opinion in Clinical Nutrition & Metabolic Care, 4(1), 57–64.

6. Martínez-Puig, D., Manzanilla, E. G., Morales, J., Borda, E., Pérez, J. F., Pineiro, C., & Chetrit, C. (2007). Dietary nucleotide supplementation reduces occurrence of diarrhea in early weaned piglets. Livestock Science, 108(1–3), 276–279.

7. Mateo, C. D., Peters, D. N., & Stein, H. H. (2004). Nucleotides in sow diets: Effects on chemical composition of colostrum and milk, performance and health of piglets. Journal of Animal Science, 82(9), 2605–2611.

8. Salobir, J. (2019). Nucleotides in animal nutrition: A review. Animal Nutrition, 5(5), 389–396.

9. Sauer, N., Mosenthin, R., & Bauer, E. (2011). The role of dietary nucleotides in single-stomached animals. Nutrition Research Reviews, 24(1), 46–59.

10. Yu, Y. H., Tsai, C. C., Hsu, H. J., & Cheng, C. H. (2002). Dietary nucleotide supplementation enhances growth performance and immunity in weanling piglets. Journal of Animal and Feed Sciences, 11(3), 431–444.